The effects of Nigella sativa on sickness behavior induced by lipopolysaccharide in male Wistar rats
نویسندگان
چکیده مقاله:
Objective: Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. Materials and Methods: The rats were divided into five groups (n=10 in each): (1) control (saline), (2) LPS (1 mg/kg, administered two hours before behavioral tests), (3-5) LPS-Nigella sativa 100 , 200 and 400 mg/kg (LPS-NS 100, LPS-NS 200 and LPS-NS 400, respectively). Open- field (OF), elevated plus maze (EPM) and forced swimming test (FST) were performed. Results: In OF, LPS reduced the peripheral crossing, peripheral distance, total crossing and total distance compared to control (pConclusion: The results of the present study showed that the hydro-alcoholic extract of NS reduced the LPS-induced sickness behaviors in rats. Further investigations are required for better understanding the responsible compound (s) and the underlying mechanism(s).
منابع مشابه
P45: The Effects of Nigella sativa on Sickness Behavior Induced by Lipopolysaccharide in Male Wistar Rats
Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. The rats were divided into five groups (n=10 in each): (1) control (saline), (2) LPS (1 mg/kg, admin...
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objective: neuroimmune factors contribute on the pathogenesis of sickness behaviors. nigella sativa (ns) has anti-inflammatory, anti-anxiety and anti-depressive effects. in the present study, the effect of ns hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (lps) was investigated. materials and methods: the rats were divided into five groups (n=10 in each): (1) control...
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عنوان ژورنال
دوره 6 شماره 1
صفحات 104- 116
تاریخ انتشار 2016-01-01
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